The dark silicon era is driving the emergence of asymmetric computing platforms consisting of cores with diverse power-performance characteristics enabling better match between a task’s requirements and the compute engine leading to substantially improved energy-efficiency. In this chapter, we discuss the challenges and opportunities offered by asymmetric multi-cores towards low-power, high-performance mobile computing. We present a comprehensive power management framework that can guarantee Quality of Service (QoS), while minimizing energy consumption within the Thermal Design Power (TDP) budget.